Linda Vargas picks up Ortiz in a bar where she works in a lesbian show with Maria Toledano. She seduces him, phones the police and kills herself. Ortiz is held on suspicion of her murder. Ortiz's wife, Rosa, visits a friend of Linda's, the Countess Anna de Monterey who tells her how Linda went into a spiral of sex and drugs after being assaulted by Ortiz as a young girl at a fair-ground. Linda became the Countess's lover, then had a disastrous love affair with Alberto, the Countess' boyfriend. Rosa also meets Maria, who holds Linda's diary, where she relates how a fake Doctor turned her away from drugs and into a nymphomaniac.
Volume I: A man named Seligman finds a fainted wounded woman in an alley and he brings her home. She tells him that her name is Joe and that she is nymphomaniac. Joe tells her life and sexual experiences with hundreds of men since she was a young teenager while Seligman tells about his hobbies, such as fly fishing, reading about Fibonacci numbers or listening to organ music.
Volume II: Joe continues to tell to Seligman the story of her life. Joe lives with Jerôme and their son Marcel and out of the blue, she loses sexual sensation in intercourse. Joe seeks kinky sex, perversions and sadomasochism expecting to retrieve her sex drive. Jerôme leaves home with Marcel and gives his son to a foster house for adoption. Then Joe is sent to therapy by her gynecologist but she does not admit that she is addicted to sex. Meanwhile Seligman tells Joe that he is virgin and helps her to understand her actions. Joe believes that Seligman is her friend, but is he?
A man named Seligman finds a fainted wounded woman in an alley and he brings her home. She tells him that her name is Joe and that she is nymphomaniac.